Hormozi-Nezhad Group

1) Optical Sensor Arrays


  Array based sensing has emerged as a powerful approach toward the detection of chemically diverse analytes. Based on cross-responsive sensor elements, these systems aim to produce composite responses unique to each analyte, in a fashion similar to the mammalian olfactory system. Chemometric pattern recognition is extremely powerful with these arrays because of their very high dimensionality.

Colorimetric Sensor Arrays

A colorimetric sensor array consisting of citrate-capped gold nanoparticles (AuNPs) for detection and discrimination of organophosphate pesticides (Ops)

The responses based on OPs induced aggregation have been subjected to statistical analysis including hierarchical cluster analysis (HCA) and linear discriminant analysis (LDA).

Chemiluminescence Sensor Arrays

CL efficiencies of four types of enhanced nanoparticle-based CL systems. The intensity of CL was altered to varying degrees upon interaction with biothiols, producing unique CL response patterns.

 These distinct CL response patterns were collected as “fingerprints” and were then identified through chemometric methods, including linear discriminant analysis (LDA) and hierarchical cluster analysis (HCA)

Fluorimetric  Sensor Arrays

A nano-based sensor array for discrimination of catecholamine neurotransmitters. Distinct fluorescence response patterns for individual catecholamine based on quenching of thioglycolic acid functionalized cadmium telluride quantum dots, by oxidation products, were employed along with the variation of fluorescence spectra of oxidation products.

2) Fluorimetric Sensors

Energy Transfer (ET) Sensors Based on

Semiconductor Quantum Dots (QDs)

Qds are composed of an inorganic core and an outer layer of surfactant molecules with physical dimensions smaller than the bulk-exciton Bohr radius. They have size-dependent emission wavelength.

Carbon Dots (CDs)

CDs are a new class of carbon nanomaterials with sizes below 10 nm, that have strong tunable luminescence.

Metallic Nanoclusters (NCs)

NCs, as a new type of luminescent nanomaterials, composed of a few to a hundred atoms and exhibit dramatically unique electronic and optical properties.

2) Colorimetric Sensors

Surface Plasmon Resonance (LSPR) Sensors Based on

Aggregation and anti-agregation of NPs

Aggregation of AuNPs in presence of D-Penicillamine (D-PC)
complex formation of Cu(II) and D-PC which inhibits aggregation of AuNPs

Gold Nanorods (GNRs)

Variation in color of solution and corresponding Vis-NIR absorption spectra GNRs

Colorimetric Detection of Glutathione Based on Transverse Overgrowth of GNRs